SPDIF Coax still creates an electrical connection, optical does not.
It sounds like a USB isolator might solve your problem as they remove any direct electrical connection between the PC and USB device. They also have their own 5v power supply which is a lot cleaner than the 5v supply coming out of a PC. For a USB powered DAC this can make all the difference in terms of noise floor.
Up to now USB isolators were a DIY thing in that you had to cobble it together yourself, i built one of the Ciruits@home kits and put together a linear power supply for it. The guys at Beezar are just about to release a complete kit, i have built and tested one of their pre-production prototypes and can confirm it performs perfectly. Keep an eye on the thread as it should be available to order very soon.
Main thread here
https://www.head-fi.org/t/703334/doodlebug-usb-isolator
Pics of my unit here
https://www.head-fi.org/g/i/1091976/beezar/sort/display_order/