It depends on whether there's any noticeable performance difference between the channels. It could be that the cathode bias resistor on one side isn't well secured, or you have a backwards cathode bypass cap, or some other issue causing that voltage to be off, or one of the tubes in question needs a few hours of run time to wake up.
Swapping the tubes between sides would help you understand if it's an issue with the build or a tube that needs some time to run in.